Thursday, 27 August 2020

OUR BRAIN IS AFFECTED BY WHAT’S ON OUR PLATES????

For decades we have been surrounded by sweet and fatty foods. And the body has not been dealing well with these eating habits. But what about the brain?

Do our mental health, our moods, and our brain abilities suffer from the wrong kind of nutrition?

We know that junk food is making us fat, but science is telling us now that it might also be shrinking our brains. Habitual intake of foods high in fat and sugar results in reprogramming of the brain. In short, our brain is affected by what’s on our plates. It all starts with our very first meals, even before birth. The brain is built up during pregnancy and its functioning, later on, depends on how it has been nourished by the expectant mother’s diet over nine months. A number of consequences of poor nutrition during gestation have been known for a long time. Mothers who ate more junk and processed foods during their pregnancy had children with more of these behaviours such as aggression, anger, and tantrums. This disquieting correlation suggests that the mother’s diet impacts the mental development of the infant.

The brain is an organ which is rich in PUFA or omega-3. Omega-3 is indispensable because the body cannot make it so it has to come from the diet. The amount of omega-3 that enters the brain is crucial for making brain cells more efficient because when these fatty acids are incorporated into the membranes of nerve cells, they improve their electrical properties. In omega 3-rich neurons, the signals propagate faster and the network is more efficient. Depriving the brain of omega-3 is linked to a risk that it will function less. The general population is deficient in omega-3 due to its insufficient, so it's important to pay attention to it especially in the prenatal developmental period when omega-3 is incorporated in large quantities into the brain. Also, in adolescence, since it is a particular time of change of diet. And, during ageing where the incorporation of omega-3 into the brain tends to be less effective, so we must increase its intake.

The first rule for a brain to run at full speed is to avoid deficiencies. But good nutrients and a varied diet should be available. The amino acid is one building-block of a protein that is key to brain function. Dopamine molecule ensures communication between neurons involved in motivation and risk-taking. The results of the blood analysis show that subjects with higher levels of tyrosine

in their blood are more willing to accept the unfair offer. In other words, what we eat can subtly alter the chemistry of the brain within hours and thus the communication between the neurons;

enough to guide some of our decisions. Since we eat three times a day, every day, we realize that food has enormous power, modifying and shaping us. So it’s important to think about how we can use food to promote our well-being and optimize our mental state. Not only does an unbalanced diet affect our brain functions and behaviour, and our meal plan interferes with everyday decisions, it is also becoming increasingly clear that diet plays a decisive role in our mood and possibly mental health.

But what about junk food, dripping with sugar and bad fats? What would happen if we ate more of that?

Recent studies show that in humans that an energy-rich diet also interferes with the hippocampus.

We see for example, that the quality of people’s diets is related to the size of their hippocampus. An overly rich diet confuses the immune system. It responds by triggering an inflammatory reaction, especially in fatty tissues. Our fat masses release substances that then propagate this inflammation throughout the body which may spread to the brain because the blood-brain barrier which normally protects the brain from inflammatory molecules may be impaired in fact by the diet and become leaky allowing traffic of molecules into the brain. The inflammation infiltrates the meninges and then triggers a surprising phenomenon

The reward circuit is a region of the brain that controls the feeling of pleasure. It is particularly responsive to sugar consumption. But eating too much ends up weakening its responsiveness

so that at the same dose, the sensations of pleasure are ultimately reduced. After a diet too rich in sugar, the brain becomes hypersensitive to images of food. The more and more you eat ice cream,

the more your reward circuitry is activated when you see an ice cream store or on television.

Scientists now consider the microbiome to be a kind of intermediary, a link between food and the brain. The main factor that influences the composition of microbes in the food we eat. Diet and the diversity of the diet is really important from the moment we’re born until we die, in shaping the composition of the microbes. So we’re beginning to realise the importance of what we eat has on what’s in our microbes, and how that’s influencing what’s going on in our brain. Our well-being depends, in one way or another, on our microbiome. A diet that is good for our mood is first and foremost a diet that is suitable for the bacteria in our intestines. Researchers are only just beginning to uncover the secrets of the remarkable relationship between nutrition and the brain. The ideal menu for our little grey cells is still largely unknown. But a balanced, diverse diet which does without processed food and sugar, and favouring fruits and vegetables, seems so far to be the best recipe for preserving the mental faculties.

My grandmother said “You are what you eat, so eat well.

Mr. GOPIKRISHNAN T.S., V Pharm. D

 

Thursday, 20 August 2020

WHY DRUGS OFTEN HAVE DANGEROUS SIDE EFFECTS FOR WOMEN?

 We all go to doctors.

And we do so with trust and blind faith that the tests they are ordering and the medications they're prescribing are based upon pieces of evidence, evidence that's designed to help us. However, the reality is that it hasn't always been the case for everyone. What if I told you that the medical science discovered over the past century had pre-trailed indiscriminately one half the population?

Doctors order the same tests, and prescribe the same medication, irrespective of patients gender- male or female.

A recent Government Accountability study revealed that 80 per cent of the drugs withdrawn from the market are due to side effects on women. Why are they discovering side effects on women only after a drug had been released to the market?

So why are we discovering unacceptable side effects on half the population after all the clinical trials that had gone through?

Well, it turns out that those cells used in that laboratory for clinical testing were male cells and the animals used in the animal studies were male animals and the clinical trials performed were almost exclusively on men.

How is it that the male model became our framework for medical research?

Let's look at a case that was popular in the USA that had to do with the sleep aid Ambien (Zolpidem). Ambien was released in the market over 20 years ago and since then, hundreds of millions of prescriptions had been written, primarily to women, because women suffer more sleep disorders than men. But just this past year, the Food and Drug Administration recommended cutting the dose in half for women only, because they realized that women metabolized the drug at a slower rate than men which caused them to wake up in the morning with more of the the active drug in their system causing a drowsy feeling in them and in turn resulting in motor accidents. Imagine how many of the motor vehicle accident could have been prevented if this type of analysis were performed and acted upon 20 years ago when this drug was first released.

How many other things need to be analyzed by gender?

World War II changed a lot of things, and one of them was this need to protect people from becoming victims of medical research without informed consent. So some much-needed guidelines or rules were set into place, and part of that was this desire to protect women of childbearing age from entering into any medical research studies.

There was fear: what if something happened to the fetus during the study? Who would be responsible? And so, the scientists thought, that this, was a blessing in disguise. Men's bodies are pretty homogeneous. They don't have the constantly fluctuating levels of hormones that could disrupt clean data. It was easier, It was cheaper. Not to mention, that there was a general assumption that men and women were alike in every way, apart from their reproductive organs and sex hormones. So, it was decided, medical research was performed on men, and the results were later applied to women. What did this do to the notion of women's health?

Women's health became synonymous with reproduction: breasts, ovaries, uterus, and pregnancy. It's this term we now refer to as "bikini medicine.”And this stayed this way until about the 1980s.when this concept was challenged by the medical community and by the public health policymakers. Virtually nothing was known about the unique needs of the female patient. Since that time, an overwhelming amount of evidence had come to light that showed us just how different men and women were in every aspect.

There is a saying in medicine:

Children are not just little adults which reminds us that children actually have a different physiology than normal adults. And it's because of this that the medical speciality of paediatrics came to light. And now researches are conducted on children in order to improve their lives.

Same thing can be said about women. Women are not just men with a different reproductive organ. But they have their own anatomy and physiology that deserves to be studied with the same intensity.

Let's take the cardiovascular system, for example.

This area in medicine has done the most, to try to figure out why it seems men and women have completely different heart attacks. Heart disease is the number one killer of both men and women, but more women die within the first year of having a heart attack than men. Men will complain of crushing chest pain like an elephant is sitting on their chest which is called typical.

Women have chest pain, too. But more women than men will complain of "just not feeling right," "can't seem to get enough air in," "just so tired lately. “Which for some reason is classified as "atypical", even though, as mentioned, women do make up almost half the population. And so, what are some of the evidence to help explain some of these differences?

If we look at the anatomy, the blood vessels that surround the heart are smaller in women compared to men, and the way that those blood vessels develop the disease is different in women compared to men. And the tests that we use to determine if someone is at risk for a heart attack, which was initially designed, tested and perfected in men aren't as good at determining that in women.

What this is doing is merely telling us that we are scratching the surface. It's about training future health care providers correctly. Because this cannot just be left up to the health care leaders. We all have a role in making a difference. But it is not so easy.

The first step towards change is awareness. This is not just about improving medical care for women. This is about personalized, individualized health care for everyone. This awareness has the power to transform medical care for men and women. The conversation has begun, and together we can all learn.

Martin Luther King, Jr. had said, "Change does not roll in on the wheels of inevitability, but comes through continuous struggle."

Ms. OLIVIA SUNNY, Pharm.D Intern.

Wednesday, 12 August 2020

THE RISE OF THE TICK-BORNE VIRUS IN CHINA!!

 

An unnoticeable tick with a high fatality rate and severe symptoms?

YES…A bug responsible for a virus so bad that it can kill you.

A virus called SFTS (Severe Fever Thrombocytopenia Syndrome).

SFTS is a viral hemorrhagic fever caused by a "phlebovirus". It is transmitted from the Asian tick called Haemaphysalis longicorniswhich is commonly found in the Americas, Asia, Africa, and the Mediterranean region. Scientists found that the tick-associated with severe fever is often passed on to humans from animals. And it also roams around forests. While the tick is the main vector of the virus, it may also be spread from person to person through blood, wounds or mucous.

There are many reasons to treat this seriously…but there is no reason to panic because this virus is not new. SFTS was first identified by a team of researchers in the Hubei and Henan provinces of China in 2009. As of 2016, SFTS like or confirmed SFTS patients has been reported in South Korea, Japan, UAE and United States outside China.

And now again in 2020, China found that SFTS infected 60 people in one area; and what’s so scary about it is that right now, up to 30% of the cases could die from it. The cases of SFTS virus first appeared in April and since then more than 37 people in East China’s Jiangsu Province have contracted with the virus and 23 people were found infected in East China’s Anhui Province. Seven people already died.

That’s why the World Health Organization listed it as one of its top 10 priority diseases.

All because of a TICK!!

And once it bites, we will experience unusual rashes and various other non-specific symptoms including respiratory tract symptoms, sudden onset of fever up to 38–41°C, headache, fatigue, myalgia, and gastrointestinal symptoms (loss of appetite, nausea, vomiting, and diarrhoea). Multiple organ failure develops rapidly in most patients (with raised concentrations of serum alanine aminotransferase, aspartate aminotransferase, creatinine kinase, and lactate dehydrogenase; and proteinuria and hematuria), and is usually accompanied by thrombocytopenia, leukocytopenia, and lymphadenopathy.

Currently, no vaccine or antiviral therapy is available to treat SFTS. The Chinese Ministry of Health initially approved the use of ribavirin to treat SFTS based on results of in vitro studies; nevertheless, the effectiveness of ribavirin to treat SFTS was evaluated in patients with a clinical diagnosis of SFTS, and no beneficial effect of ribavirin on platelet recovery or viral load reduction was noted. As a supportive measure, treatment with plasma exchange followed by convalescent plasma therapy from SFTS survivors, intravenous immunoglobulin and corticosteroids had also given. 

Unfortunately, all these therapies have not shown any encouraging results. While new cases of the novel Coronavirus is still popping up in China, the country is facing yet another potentially contagious viral infection. This time, it's jumping from ticks to people.

The rapid urbanization, followed by widespread rural-to-urban migration of the human population, intensive long-distance trade, and explosive short-term travel for shopping, has led to substantial health risks including air pollution, occupational and traffic hazards, and altered diets and activity. All of these changes in human activity, together with increased contact between human beings and their pets and nature, have probably contributed to the increasing the abundance of tick exposures over there.

The virus could undergo rapid evolution by gene mutation, reassortment and homologous recombination in tick vectors and vertebrate reservoir hosts. And thus, the disease has become a substantial risk to public health, not only in China, but also in other parts of the world.

Since no specific treatments of SFTS are available, avoiding tick bites is the most important measure to prevent the infection and transmission of SFSTV. People are advised not to go into jungles and bushes during an outbreak since ticks are most commonly found in wooded areas. Check your body for ticks after being outdoors. Treat clothing’s and gear with products containing 0.5% permethrin.

These precautions should be strictly followed during the summer season, as ticks breed actively during that time. if not, A TINY BUG CAN BE SOMEBODYS LAST TOUCH BEFORE DEATH!

May all these things that can take our lives remind us that life can be so fragile; we need to live our lives as if every day could be our last one.

Ms JEEVA ANN JIJU Pharm.D Intern

Thursday, 6 August 2020

BCG VACCINE: A HYPE OR HOPE AGAINST COVID-19 FLAREUP?


In the race against time, in the middle of death and devastation, many researchers are burning the candles on both ends in discovering an effective vaccine against COVID-19 and some have pinned their hopes on vaccines that already exist, the one that is right under our nose- the BCG vaccine as "The game-changer".

The Bacillus Calmette-Guerin (BCG) vaccine is administered to protect against tuberculosis by inducing an adaptive immune response in the body together with some non-specific effects.  This knowledge has reciprocated to generate the conjecture that this vaccine can also offer protection against Severe Respiratory Syndrome Corona-virus 2 (SARS-CoV-2). BCG-induced innate immunity has shown a reduction of viremia with RNA viruses in experimental human models, reduction of the incidence and severity of respiratory infections, and exertion of other antiviral effects.  Randomized trials in older adults and observational studies in children show that BCG markedly reduces acute respiratory infection. It induces genome-wide epigenetic reprogramming of innate immune cells leading to long-term functional changes and modulation of immunity.
Presently, WHO does not recommend the usage of BCG vaccination to treat COVID-19 because of the absence of any concrete evidence suggesting that the vaccine prevents the SARS-CoV-2 infection? But in contrast to this, there is evidence for the potential biological basis of BCG cross-protection from severe COVID-19. A strong correlation between the BCG index and COVID-19 mortality in different socially similar European countries has indicated that every 10% increase in the BCG index was associated with a 10.4% reduction in COVID-19 mortality. More broadly, countries with current BCG vaccination had lower deaths as compared to countries with lack of, or interrupted, BCG vaccination.
The silver lining is VPM1002, an improved Recombinant BCG with the Mycobacterium bovisurease C gene replaced by the listeriolysin O-encoding gene hly. Compared to the parent vaccine, the advantages of  rBCG vaccine include safety,  more important protective heterologous effects and scalability, which poses VPM1002 to be a promising intervention against SARS-CoV-2.Recent trials have shown that VPM1002 can also be effective against cancer and prevent recurrence of bladder tumours.
Thanks to its broad spectrum of protection and to the prompt availability of the product, showing the efficacy of VPM1002  as  a fundamental step in flattening the curve of the current COVID-19 pandemic and will constitute a strategic advantage for the future: the mechanism of action of VPM1002 is thought to guarantee protection against future viral pandemics or in case of mutations in the current Sars-CoV2 virus, which might impair the efficacy of COVID-19 vaccines currently under development.   

Finding a vaccine or a treatment against the new coronavirus is a race against time, but thankfully a lot of promising projects are already very advanced. Some promising candidates are The University of Oxford and AstraZeneca’s AZD1222 (ChAdOx1nCoV-19), Pfizer and BioNTech’s BNT 162, India’s indigenous Covaxin, etc.
One of the main reasons, why it is essential to stick to WHO's recommendation is that there might be a bare possibility that up-regulation of the immune system by BCG vaccination and its non-specific effects will aggravate COVID-19 in a minority of patients with severe ailmentsTwo clinical trials addressing this question are underway, and WHO will evaluate the evidence when it is available. As applying “QUICK FIX” and “SHORTCUTS” can lead to disastrous consequences, let’s rely on the results from clinical trials and find whether the BCG vaccine is a hype or hope against COVID-19.

Ms. Elza Baby, 7th Semester B.Pharm